Bye Bye, Dark Spots! Everything to Know About Thiamidol for Hyperpigmentation

What Is Thiamidol?

Helps Fade Pigment

Thiamidol has been compared to hydroquinone, an extremely powerful (and controversial) lightening ingredient. Many professionals advise against hydroquinone, and it’s also been banned in parts of the world. In fact, hydroquinone is on the IPSY Out List. While minimal research exists on thiamidol, from what we know, this ingredient has a similar ability to help fade pigment, but without irreversible side effects like ochronosis. 

“Hyperpigmentation is a major concern that affects an estimated 80 million Americans,” Dr. Galaria says. “It’s caused by excess brown pigment or melanin. We know that the production of melanin can be increased by UV exposure, injury (post-inflammatory hyperpigmentation), and certain medical and hormonal conditions.”

Helps Prevent Pigment 

In addition to fading already-existing pigment, “Thiamidol has been shown to block tyrosinase and therefore slow hyperpigmentation,” Dr. Galaria says. “As the skin cells shed in the top layers of our skin, patients gradually see their brown patches or pigment spots fade. That said, the treatment of pigment and especially melasma is most effective when done multi-modally with an approach that includes sunscreen, vitamins, and topical treatments.” 

Are There Any Side Effects?

Though there have been only small studies that have evaluated thiamidol’s safety, Dr. Smith says up to 8% of people can develop an allergic reaction called contact dermatitis. “This is a delayed allergic rash that can happen two to four days after application and can last for three weeks,” he explains. 

Due to the high risk of allergic reaction, “I’d absolutely recommend anyone new to thiamidol do a patch test first,” the doctor advises. “This can be done on a small area of your forearm where you apply the product twice daily for a week. Contact dermatitis is unfortunately a risk for most ‘actives' you find in skincare products, which is why I created my own skincare line that eliminates 128 of the most common allergens in skincare.”

How to Use Thiamidol for Your Skin

While little research is available on thiamidol formulation, what we do know is that EUCERIN had it packed into a serum, meaning we’d apply it the way we would any other serum. We’d start by cleansing the skin, applying the serum, letting it sit for at least a minute, and then topping it off with moisturizer and SPF.

Because products with thiamidol are tough to track, we’re recommending a few favs that can potentially have similar results. The vitamin C–based GOLDFADEN MD Light Treatment - Dark Spot Corrector helps with sunspots, melasma, and acne scars. We also stand by the cult-favorite MURAD Rapid Age Spot and Pigment Lightening Serum for those pesky isolated dark marks.

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